岳峰 (M.D., Ph.D.), 正规外围买球十大平台教授、博士研究生导师。首都医科大学神经病学专业医学博士、临床医学专业博士后。北京大学光华管理学院高级管理人员工商管理硕士。1994-2003年在新疆医科大学第一附属医院神经内科从事临床诊疗、教学与科研工作，历任主治医师，讲师，副主任医师，副教授。2008-2020年在首都医科大学宣武医院/北京市老年病医疗研究中心工作，历任副主任医师、副研究员、研究员。

长期从事神经系统疾病临床诊疗、基础与转化医学研究工作。参与建立了国内早期获得aaalac国际资质认证的专业灵长类动物实验室，负责实验技术平台运营管理。探索实践了基于人类疾病灵长类动物模型及其灵长类动物实验平台的转化医学研究与新药研发服务模式，拓展了多项与国内外新药研发机构、生物技术公司以及大学、科研院所的研究合作。曾在美国威斯康星国家灵长类研究中心及制药企业等机构学习培训。

当前主要工作是开展中枢神经系统疾病的基础与转化医学研究，以及基于非人灵长类模式动物的脑科学/转化医学研究条件支持平台的运行。

  研究方向： 

1）神经退行性疾病（阿尔茨海默病、帕金森氏病）发病学研究。应用系统性、多维尺度方法开展神经退行性疾病早期发病与演化机制的研究。

2）中枢神经系统疾病神经功能重建研究。基于神经系统疾病拟临床灵长类动物模型以及微生理系统仿真模型，开展神经功能重建研究。

  课题、专利与奖项： 

主持国家重点研发计划“干细胞及转化研究”重点专项课题，神经干细胞在重大神经疾病猴模型中的临床前评估”；“十二五”国家高技术研究发展计划 (863计划)“代谢类重大疾病灵长类模型的研发”课题以及国家自然科学基金面上项目。参与科技创新2030-“脑科学与类脑研究”重大项目”脑疾病模型猴制备与疾病早期诊断指标建立”课题。获授权发明专利7项，已受理公开的发明专利、实用新型专利12项；获省级科学技术奖2项。

  学术论文（*为通讯作者）： 

1.  Xinxin Huang, Shanshan Huang, Fangyan Fu, Junzhen Song, Yuling Zhang, Feng Yue*. Characterization of preclinical Alzheimer’s disease model: spontaneous type 2 diabetic cynomolgus monkeys with systemic pro-inflammation,positive biomarkers and developing AD-like pathology. Alzheimers Research & Therapy, 2024, 16(1):52.

2.  Jiajun Deng, Bin Liu, Qian Tao, Yanyu Luo, Yi Zhu, Xinxin Huang , Feng Yue*. The co-oligomers of Aβ42 and human islet amyloid polypeptide exacerbate neurotoxicity and Alzheimer-like pathology at cellular level. Neuroscience.2024,S0306-4522(24)00155-6

3.  Yu Bao, Chaoning Gan, Zuyue Chen, Zhongquan Qi, Zhiqiang Meng, Feng Yue*. Quantification of Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys. Brain Sciences.2023, 13(8), 1153.

4.  Tang L, Xu N, Huang M, Yi W, Sang X, Shao M, Li Y, Hao ZZ, Liu R, Shen Y, Yue F, Liu X, Xu C, Liu S. A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson's disease. Nat Commun. 2023,14(1):7497.

5.  Fan Yang; Xueyan Jiang; Feng Yue; Luyao Wang; Henning Boecker; Ying Han; Jiehui Jiang. Exploring dynamic functional connectivity alterations in the preclinical stage of Alzheimer’s disease: an exploratory study from SILCODE, Journal of Neural Engineering, 2022, 19(1): 016036-016036

6.  Su Feng , Ting Zhang, Wei Ke , Yujie Xiao , Zhong Guo , Chunling Lu, Shuntang Li , Zhongxin Guo, Yuanyuan Liu , Guohe Tan , Yingying Chen , Feng Yue , Yousheng Shu, Chunmei Yue  and Naihe Jing .The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys. Life Medicine. 2022, 1(2):196–206.

7.  Feng Yue*, Su Feng, Chunling Lu, Ting Zhang, Guoxian Tao, Jing Liu, Chunmei Yue, Naihe Jing. Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer’s disease in nonhuman primates. iScience 2021, 24(10), 103207.

8.  Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang , Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi Li. Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis. Cell Death Dis. 2021,12(1):81.

9.  Yan Sun, Chuang Guo, Lin Yuan, Wen Li, Zhan-You Wang, Feng Yue*, Jia-Yi Li. Cynomolgus Monkeys with spontaneous Type-2-Diabetes-Mellitus-like pathology develop alpha-synuclein alterations reminiscent of prodromal Parkinson's Disease and related diseases. Front Neurosci. 2020, 14:63.

10.  Li S, Zhang H, Wang A, Liu Y, Liu H, Yue F, Abulaiti X, Zhang C, Li L. Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain. Mol Med. 2019 Mar 29;25(1):9.

11.  Song Zhang, Yilin Song, Mixia Wang, Guihua Xiao, Fei Gao, Ziyue Li, Guoxian Tao, Ping Zhuang, Feng Yue*, Piu Chan & Xinxia Cai.Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays. Microsystems & Nanoengineering. 2018, 4, 17070.

12.  Li Z, Chen X, Wang T, Gao Y, Li F, Chen L, Xue J, He Y, Li Y, Guo W, Zheng W, Zhang L, Ye F, Ren X, Feng Y, Chan P, Chen JF. The Corticostriatal Adenosine A2A Receptor Controls Maintenance and Retrieval of Spatial Working Memory. Biol Psychiatry. 2018,83(6):530-541.

13.  Xu S, Zhang Y, Zhang S, Xiao G, Wang M, Song Y, Gao F, Li Z, Zhuang P, Chan P, Tao G, Yue F, Cai X. An integrated system for synchronous detection of neuron spikes and dopamine activities in the striatum of Parkinson monkey brain. J Neurosci Methods. 2018 Jul 1;304:83-91.

14.  Yue F, Zhang G Quintero JE, Gash DM, Zhang Z Role of social interaction, exercise, diet, and age on developing and untreated diabetes in cynomolgus monkeys. Exp Gerontol. 2017 Jun 15;96:82-88.

15.  Ren G, Yan J, Tao G, Gan Y, Li D, Yan X, Fu Y, Wang L, Wang W, Zhang Z, Feng Yue, Yang X. Rapid focal cooling attenuates cortical seizures in a primate epilepsy model. Exp Neurol. 2017 Sep;295:202-210.

16.  Yue F, Zeng S, Tang R, Tao G, Chan P. MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes. Neurosci Bull. 2017 Feb;33(1):17-27.

  招生需求： 

招收具有生物医学工程、生物学、医学、神经生物学、细胞生物学、实验动物等相关专业背景硕士与博士研究生，常年招收博士后。

另招收电子信息、计算机、生物信息学等专业背景的硕士研究生，主要参与开展行为学表型识别与分析、影像处理与分析、基于生物信息学与机器学习的预测模型、微生理系统模型仿真设计与数据采集分析等方面的研究工作。

联系方式：fyuee@hainanu.edu.cn